Effects of yoga on epigenetics, and gene expression: Emerging evidence

Yoga and Epigenetics

Abstract

Yoga is being used as a form of physical exercise and for stress management worldwide, with documented benefits. Recently, research has begun to explore its potential influence on epigenetics and gene expression. The interplay between yoga, gene expression, and epigenetic mechanisms is complex, with research increasingly suggesting that yoga may have profound effects on the molecular processes governing our health. It has been shown to influence molecular processes, including gene expression and epigenetic regulation, which may lead to potential clinical benefits. Various mind-body therapies (MBT) are found to epigenetically affect genes implicated in inflammation, stress, and distress, offering potential therapeutic benefits. Meditative practices have been shown to have a positive impact on stress-reduction pathways, which are known to be epigenetically sensitive, suggesting the importance of integrating these practices into mainstream medicine. Additionally, a yoga-based lifestyle intervention has been found to affect gene expression related to oxidative stress, inflammation, and aging. Furthermore, yoga practice has been shown to upregulate the expression of the Methylenetetrahydrofolate reductase gene, involved in critical metabolic processes, and has implications for various diseases. This perspective aims to synthesize current scientific evidence on how yoga might influence epigenetics and gene expression, thereby offering insights into its potential clinical benefits.