The antioxidative role of Aegle marmelos Linn. on colchicine induced experimental rat model of Alzheimer’s disease

Abstract

Antioxidant plays a crucial role in the management of neurodegenerative diseases including Alzheimer's disease. A number of Indian medicinal plants have been used in the traditional system of medicine (Ayurveda) for the management of neurodegenerative diseases including Alzheimer's disease. Some of these plants have already been reported to possess strong antioxidant activity. Aegle marmelos (AM) Linn., a fruit of common use, is rich in vit-E, beta-carotene, flavonoids and flavonols. The effect of chronic oral treatment of aqueous pulp extract of AM (250 mg/ kg B.W) was studied in Holtzman strain adult albino rats of both sexes. The behaviour study, antioxidant level Superoxide dismutase (SOD), Catalase (CAT), Reduced glutathione level (GSH) and Lipid peroxidation level were studied in different brain areas such as Cerebral cortex (CC), Cerebellum (CB), Midbrain (MB), Caudate nucleus (CN) and Pons & Medulla (PM) in colchicine induced experimental Alzheimer rat model before and after treatment with AM. The result revealed that chronic treatment with AM pulp extract markedly increased the number of correct choices in radial Y arm maze task, significantly decreased Lipid peroxidation level, significantly increased SOD, CAT and Reduced glutathione level in the different parts of the brain. The present study demonstrated that the antioxidant property of AM property may be beneficial for the management of colchicine induced rat model of Alzheimer's disease.